Preparation method of ethyl carbamate – How to prepare ethyl carbamate?

Ethyl carbamate (hereinafter referred to as AME) is a common and important organic chemical substance and an important organic synthesis intermediate, widely used in Medicines, dyes, pesticides, spices and other fields. This article will introduce readers to the preparation method and production process of ethyl carbamate, and explain the relevant content in detail.

Part 1: Overview of ethyl carbamate

Ethyl carbamate, the chemical formula is CH3NHCOOCH2CH3, which can also be expressed as N-formyl-N-acetylmethylamide or N-methyl Base-N-acetylformamide. It is a low-toxic, volatile, colorless and transparent liquid with a weak sour and ammonia smell. It has good solubility and can be dissolved in water, ethanol, acetone, benzene and other organic solvents.

One of the main uses of ethyl carbamate is as a pharmaceutical intermediate, used to synthesize a variety of anti-cancer drugs and drugs for the treatment of cardiovascular and cerebrovascular diseases. In addition, it can also be used to synthesize organic compounds such as dyes, pesticides, and spices.

Part 2: Preparation method of ethyl carbamate

①Aminolysis method

Aminolysis method is an original method for preparing ethyl carbamate. Mix ethyl formate and ammonia water in a certain ratio and control the temperature and reaction time in the reactor to obtain the product. However, this method not only has strict reaction conditions, but also has a low yield of only 60%-70%.

　② Synthesis method

The main method for preparing ethyl carbamate today is the synthesis method. Ethyl carbamate can be obtained by the condensation reaction of ethyl formate and amine formate. We will describe both synthesis methods in detail.

A. Acid catalyzed condensation method

This method uses an acid catalyst as a catalyst, adds amine formate and ethyl formate into the reactor, and controls the reaction temperature and time. Product is obtained. As the acid catalyst, sulfuric acid, phosphoric acid, ammonium chloride, etc. can be used.

B. Alkali-catalyzed condensation method

This method uses an alkaline catalyst as a catalyst, adds amine formate and ethyl formate into the reactor, and controls the reaction temperature and time to obtain product. As the alkali catalyst, sodium hydroxide, potassium hydroxide, ammonia water, etc. can be used.

Part Three: The Production Process of Ethyl Carbamate

According to the above preparation method, the production process of ethyl carbamate can be divided into two types, namely the ammonolysis production process and the Synthetic production process. Generally speaking, the ammonolysis method is simpler, but the technology is more difficult and the yield is lower. The synthesis rules are more mature, stable, the process is simple, and the output is large.

In addition to the preparation method, the production process of ethyl urethane also includes the following links:

① Selection of raw materials

Production of ethyl urethane There are many kinds of raw materials, among which amine formate and ethyl formate are the main raw materials. In order to ensure product quality, the purity, quantity and quality requirements of raw materials are relatively high.

　② Purification of foreign matter

In the process of producing urethane, if foreign matter exists, it will affect the quality of the product, so purification is required to ensure product quality.

　③ Optimization of the preparation process

Different preparation methods will lead to different product properties. We need to optimize the preparation process according to the actual situation so that the product has better properties.

Part 4: Summary and Outlook

As an important organic chemical substance, ethyl carbamate has broad application prospects. This article introduces the preparation method and production process of ethyl carbamate in detail, hoping to be helpful to readers. In the future, with the continuous development of science and technology and the continuous innovation of technology, the application of urethane will be more extensive, bringing better economic and social benefits.