Preparation of N-succinimide tert-butyl carbonate_Industrial additives

Preparation background and overview of N-succinimide tert-butyl carbonate

N-Hydroxysuccinimide fatty acid esters can be prepared by reacting the thallium salt of N-hydroxysuccinimide with an appropriate fatty acid in the presence of dicyclohexylcarbodiimide and reacting the salt with The acid chloride reacts and the succinimide ester is then recovered in excellent yields to form insoluble thallium chloride, which can be removed by filtration. The reaction medium used to form the succinimide ester can be any suitable solvent, such as chloroform, dichloromethane, diethyl ether, dimethylformamide, etc.

The reaction will be complete in about 1 hour at room temperature. Thallium can be recycled. N-Succinimide tert-butyl carbonate is a BOC-protected N-hydroxysuccinimide, which can be used as a pharmaceutical and chemical synthesis intermediate. If N-succinimide tert-butyl carbonate is inhaled, move the patient to fresh air; if skin contact occurs, take off contaminated clothing, rinse the skin thoroughly with soap and water, and seek medical attention if you feel unwell; if In case of eye contact, separate eyelids, rinse with running water or saline, and seek medical attention immediately; if ingested, rinse mouth immediately, do not induce vomiting, and seek medical attention immediately.

Aluminum magnesium carbonatePreparation structure of N-succinimide tert-butyl carbonate

Preparation of N-succinimide tert-butyl carbonate

The preparation of N-succinimide tert-butyl carbonate is as follows: add a solution of isobutyl chloroformate (26 ml, 200 mmol) in batches to 600 ml of chloroform, and the dimethyl ester of N-hydroxysuccinimide Cyclohexylamine salt (HOSu, 49.28 g, 200 mmol). After the resulting suspension was stirred overnight, the precipitated DCHA hydrochloride was filtered off and washed with chloroform. Dilute the concentrated filtrate (approximately 50ml) and washings with ml ethyl acetate (EtOAc) and use 10% citric acid (4 x 100ml), brine (2 x 100ml), 10% sodium bicarbonate (3 x 100zirconium carbonate) ml) and brine (4 x 100 ml), then dried (magnesium sulfate), filtered and concentrated to approximately 100 ml. 100ml. Dilute with diethyl ether and precipitate with hexane to obtain 26.6g N-succinimide tert-butyl carbonate (yield 62%), melting point 33-35°C.