Application examples of H-β-(2-pyridine)-DL-ALA-OH_Industrial additives

Background and overview of application examples of H-Β-(2-pyridine)-DL-ALA-OH

H-Β-(2-pyridine)-DL-ALA-OH is also called 2-amino-3-(pyridin-2-yl)propionic acid. It is an amino acid. There are reports in the literature that it can be used to prepare MMP- 12 inhibitors and glycine B antagonists.

Application examples of H-Β-(2-pyridine)-DL-ALA-OH

Application examples of H-Β-(2-pyridine)-DL-ALA-OH Application 1.

H-B-(2-pyridine)-DL-ALA-OH can be used to prepare MMP-12 inhibitors with the following structure. A major feature of aging skin and prematurely aged skin is a high degree of fragmentation of the dermal matrix, in which MMPs are known to play a major role in protein degradation, such as that of elastin and collagen, which in turn affects the structural integrity of the dermis. . Therefore, protecting extracellular matrix proteins (e.g., elastin and collagen) in aging or photoaged human skin by reducing MMP is of great importance to delay the clinical manifestations of skin aging (e.g., wrinkles, sagging, and sagging) of cyanobenzoate. important.

Application examples of H-Β-(2-pyridine)-DL-ALA-OH Application 2.

H-aminophenylboronic acid pinacol ester-B-(2-pyridine)-DL-ALA-OH can also be used to prepare glycine B antagonists with the following structure. NMDA receptor antagonists may have a wide range of therapeutic uses. They act on different recognition regions located within the cation channel to achieve inhibition of NMDA receptor function, such as the primary conduction region and the strychnine-insensitive glycine region (glycine B). ), polyamine region and phencyclidine region. Receptor desensitization is a physiological process that serves as an intrinsic control mechanism that prevents long-term neurotoxic activation of glutamate receptors but allows transient physiological activation. For NMDA receptors, the co-agonist glycine serves as an endogenous ligand and can hinder this desensitization by activating the glycine B region. Interestingly, ischemia not only increases extracellular glutamate concentration, but also increases its glycine concentration. Although the latter effect is not as significant as the former, it lasts much longer. Therefore, in a similar situation, some good glycine B antagonists can potentiate desensitization of NMDA receptors to their physiological levels to restore normal synaptic transmission.

References

[1] Pickett S D , Green D V S , Hunt D L , et al. Automated Lead Optimization of MMP-12 Inhibitors Using a Genetic Algorithm[J]. ACS Medicinal Chemistry Letters, 2011, 2(1):28-33.

[2] From PCT Int. Appl., 2010037533, 08 Apr 2010