Main applications of 2,3-dimethyl-5-bromopyridine_Industrial additives

The main application background and overview of 2,3-dimethyl-5-bromopyridine

2,3-Dimethyl-5-bromopyridine is an organic intermediate that can be prepared from 2,3-dimethylpyridine in one step. Can be used as pharmaceutical intermediates.

Main application preparation of 2,3-dimethyl-5-bromopyridine

To a solution of 2,3-dimethylpyridine (0.51 mL) in fuming sulfuric acid (10 mL) was added dropwise bromine (0.3 mL) at 155°C over 2 hours. The reaction mixture was then heated at 155°C for 16 hours. After cooling to room temperature, the mixture was poured onto ice and the pH was adjusted to 10 with aqueous sodium hydroxide solution. The product was extracted into ethyl acetate (3 × 40 mL), and the organic layer was dried (MgSO₄), concentrated under reduced pressure and purified on silica to give 2,3- as a yellow oil. Dimethyl-5-bromopyridine.

Main applications of 2,3-dimethyl-5-bromopyridine

PCT Int. Appl., 2008070740 reported that 2,3-dimethyl-5-bromopyridine can be used to synthesize compound 371. Compound 371 is a compound with anticancer activity, more specifically involving the inhibition of PI3 kinase activity. The invention also relates to methods of using said compounds for the in vitro, in situ and in vivo diagnosis or treatment of mammalian cells or related pathological conditions. Phosphatidylinositol is one of many tetrahydrofuran phospholipids found in cell membranes. In recent years, it has become clear that PI plays an important role in intracellular signal transduction. Cell signaling through 3′-phosphorylated phosphoinositides is involved in diverse cellular processes such as malignant transformation, growth factor signaling, inflammation, and immunity. The enzyme responsible for generating these phosphorylated signal products, phosphatidylinositol 3-kinase (also known as PI 3-kinase or PI3K), was identified to be associated with the activity of viral oncoproteins and growth factor receptor tyrosine kinases.