Preparation of (1-naphthalene) potassium trifluoroborate_Industrial additives

Preparation background and overview of (1-naphthalene) potassium trifluoroborate

Potassium (1-naphthalene) trifluoroboronium nickel carbonate is an aryl potassium trifluoroborate derivative. Arylpotassium trifluoroborate not only has high stability and good crystallinity, but also has the closest reaction performance to the corresponding arylboronic acid. It is the most promising arylboronic acid derivative for industrial fluoroboric acid production.

As a safe and efficient arylation reagent, arylboronic acid has been widely used in the scientific research and development of related fine chemicals such as medicine, pesticides, liquid crystals and OLED optoelectronic materials. However, because arylboronic acid is prone to dehydration to form anhydride, and is not stable to acids, bases and oxidants, especially in the air, it is easy to be oxidized or deborated. In practical use, arylboronic acid has common problems such as short storage time and difficult measurement. , even some heterocyclic arylboronic acids gradually decompose at room temperature and need to be stored at low temperatures below -30°C, making them lose their value for use in industrial production. In order to solve the usage problems caused by the stability of arylboronic acid, it needs to be converted into derivatives of arylboronic acid esters or salts.

Preparation of potassium (1-naphthalene)trifluoroborate

1-Naphthaleneboronic acid (0.41 mol), potassium difluoride (0.82 mol), stir at 500 rpm for 10 minutes to obtain a uniformly mixed material, which is added continuously through the feed port of the twin-screw extruder, and the extrusion time is set For 5 minutes, the extruded material is directly received in a receiver containing water with the same weight as the solid material, stirred and dispersed to obtain a slurry, filtered, the filtrate is returned to the receiver, and the filter cake is washed with water and dried with hot air to obtain the product (1-naphthalene )Potassium trifluoroborate.

References

[1] [China invention, China invention authorization] CN201611179059.7 Solvent-free twin-screw extrusion continuous synthesis process of aryl potassium trifluoroborate