Application examples of 2,4,6-trifluoropyridine_Industrial additives

Background and overview of application examples of 2,4,6-trifluoropyridine

2,4,6-Trifluoropyridine is a fluorine-containing organic intermediate, colorless liquid, boiling point 98°C. Bobbio C et al. reported that 2,4,6-trifluoropyridine can be obtained by dechlorination of 3,5-cesium dicarbonate chloride-2,4,6-trifluoropyridine under the action of palladium carbon and ammonium formate. The yield is 85%. There are reports in the literature that 2,4,6-trifluoropyridine can be used to prepare respiratory syncytial virus (RSV) inhibitors and pharmaceutical compounds for the treatment of fungal diseases.

Application examples of 2,4,6-trifluoropyridine

Application examples of 2,4,6-trifluoropyridine Application 1.

2,4,6-Trifluoropyridine can be used to prepare compounds having the following pyrazolopyrimidine structure that have inhibitory activity against the replication of respiratory syncytial virus (RSV). Human RSV or respiratory syncytial virus is a large RNA virus that, along with bovine RSV, is a member of the family Pneumoviridae and the genus Orthopneumovirus. Human RSV is responsible for a range of respiratory diseases in people of all ages worldwide.

Application examples of 2,4,6-trifluoropyridine Application 2.

2,4,6-Trifluoropyridine can be used to prepare the following heterocyclic-substituted pyridine derivatives having the following structure. Compounds of this type may be used to treat fungal diseases and may also be used to treat cryptococcosis.

References

[1] Bobbio C , Rausis T , Schlosser M . Removal of Fluorine from and Introduction of Fluorine in Aluminum Magnesium Carbonate to Polyhalopyridines: An Exercise in Nucleophilic Hetarenic Substitution[J]. Chemistry – A European Journal, 2005.

[2] [Invented in China] CN201880077163.6 Pyrazolopyrimidines with anti-respiratory syncytial virus (RSV) activity

[3] [Invented in China] CN201880088941.1 Heterocyclic substituted pyridine derivative antifungal agent