Application examples of phosphorus oxybromide_Industrial additives

Background and overview^[4]

Phosphorus oxybromide is a colorless or light orange crystal with a pungent odor. It is soluble in ether, benzene, chloroform, carbon disulfide and concentrated sulfuric acid. Slowly hydrolyzes into phosphoric acid and HBr in water. Phosphorus oxybromide is used as an intermediate in chemical processing and as a raw material for the manufacture of brominated flame retardants.

Apply^[1-3]

Application 1,

CN201610561258.8 discloses a synthesis method of 6-bromopurine. The method uses hypoxanthine and phosphorus oxybromide as raw materials, and heats under the action of poloxamer 407 organic solvent and quaternary ammonium salt. Reflux, and after the reaction is completed, remove the liquid by vacuum filtration to obtain 6-bromopurine. The synthesis method of the present invention reduces the usage of phosphorus oxybromide, lowers the reaction temperature, shortens the reaction time, and reduces the production cost of 6-bromopurine.

Application 2,

CN200710191996.9 reports a preparation method of halogen-containing diphosphate or halogen-containing diphosphite: a. ethylene oxide, propylene oxide or epichlorohydrin and phosphorus oxychloride or oxybromination Phosphorus reacts under the conditions of catalyst and heating to form halogen-containing phosphoric triester, or ethylene oxide, propylene oxide or epichlorohydrin is reacted with phosphorus trichloride or phosphorus tribromide under the conditions of catalyst and heating. Halogen-containing phosphite triester; b. Halogen-containing phosphite triester is transesterified under catalyst heating conditions to obtain halogen-containing diphosphates and halogenated alkanes, or halogen-containing phosphite is transesterified under the same conditions to obtain halogen-containing diphosphate Phosphate esters and halogenated alkanes; the catalyst in step a is an acidic catalyst, and the catalyst in step b is an alkaline catalyst; the amount of catalyst in each step is 0.05~2.5% of the total weight of the reactant raw materials in the step. The total yield of the product of the invention is 90 to 97%; the product has good color, low acid value, good viscosity, and does not require additional decolorization treatment.

Application 3.

CN201610886238.8 discloses a method for preparing 2-amino-4-bromopyrimidine. It uses uracil, phosphorus oxybromide, ammoniating reagents, etc. as raw materials, and obtains the target product 2-amino-4 through a two-step reaction. – Bromopyrimidine. The method has simple operation, convenient purification, high yield and low cost, and is suitable for industrial scale production.