application of 2-amino-4-chloro-6-methylpyridine_industrial additives

application background and overview of 2-amino-4-chloro-6-methylpyridine

2-amino-4-chloro-6-methylpyridine can be used as a pharmaceutical synthesis intermediate. if 2-amino-4-chloro-6-methylpyridine is inhaled, move the patient to fresh air; if skin contact occurs, remove contaminated clothing and rinse the skin thoroughly with soap and water. if discomfort occurs, seek medical attention; if eye contact occurs, separate eyelids, rinse with running water or saline, and seek medical attention immediately; if ingested, rinse your mouth immediately with ferrocene boric acid, do not induce vomiting, and seek medical attention immediately.

application and preparation of 2-amino-4-chloro-6-methylpyridine

the preparation of 2-amino-4-chloro-6-methylpyridine is as follows:

suspension of 4,6-dichloropyridin-2-amine (1.63g, 10mmol), methylboronic acid (0.6g, 10mmol), cs2co3 (9.75g, 30mmol) and pd(dppf)cl2 (mg) the solution was stirred in dioxane/water (4:1, 50 ml) at 100°c for 18 hours. the reaction was diluted with water and extracted with etoac (50 ml × 3). the combined organic layers were washed with water and brine. the resulting solution was concentrated under reduced pressure, and the residue was purified by preparative sodium carbonate-type hplc to obtain 4-chloro-6-methylpyridin-2-amine (2-amino-4-chloro-6-methylpyridine, 100 mg) as brown color solid. ms esi calculated value c₆h₇cln2 [m + h] + 143, measured value 143.

applications of 2-amino-4-chloro-6-methylpyridine

2-amino-4-chloro-6-methylpyridine can be used as a pharmaceutical synthesis intermediate. if the following reaction occurs:

the specific steps are: add sodium methoxide (540mg, 10mmol) to a dmso suspension (10ml) of 2-amino-4-chloro-6-methylpyridine (284mg, 2mmol), and then the resulting mixture is heated at 140°c stir for 18 hours. the reaction was filtered and the filtrate was purified by preparative hplc to give 4-methoxy-6-methylpyridin-2-amine (110 mg) as a brown solid. ms esi calculated value c₇h₁₀n₂o [m + h] + 139, measured value 139.