Application of dodecaethylene glycol monomethyl ether_industrial additives

Background and overview^[1-2]

Dodecaethylene glycol monomethyl ether, also known as dodecaethylene glycol monomethyl ether, is a kind of oligoethylene glycol monomethyl ether. Alcohol derivatives. There are literature reports that dodecaethylene glycol monomethyl ether can be used to prepare polyol monomethyl ether trimethylsilane or ribavirin derivatives.

Application^[1-2]

Application 1.

Dodecaethylene glycol monomethyl ether can be used to prepare polyols Monomethyl ether trimethylsilane. Polyol monomethyl ether trimethylsilane can be used as a lithium battery electrolyte additive. The preparation steps are as follows:

①Put compound I into the reaction kettle, and then add cation exchange resin into the reaction kettle as a catalyst;

②Add compound I to the reaction kettle dropwise Manwu II, as the reaction proceeds, ammonia will be produced as a by-product, and the dripping temperature is controlled at 10°C ~ 100°C;

③ After the dripping is completed, the reaction kettle is heated at 10°C ~ 120°C The heat preservation reaction is carried out at a temperature of Methyl ether trimethylsilane.

Compound Ⅰ is hexamethyldisilazane; compound Ⅱ is selected from ethylene glycol monomethyl ether, diethylene glycol monomethyl ether, triethylene glycol monomethyl ether, and tetraethylene glycol monomethyl ether. Methyl ether, hexaethylene glycol monomethyl ether, octaethylene glycol monomethyl ether, decaethylene glycol monomethyl ether, dodecaethylene glycol monomethyl ether, propylene glycol monomethyl ether, dipropylene glycol monomethyl ether, triisopropylene glycol One of the monomethyl ethers.

Application 2.

Dodecaethylene glycol monomethyl ether can be used to prepare the following ribavirin derivative. The ribavirin derivative can overcome the problems of hemolytic side effects and long residual time in the human body existing in the existing technology.

References

[1] [China invention, China invention authorization] CN201510323131.8 Polyol mono Preparation method of methyl ether trimethylsilane

Non-foaming surfactant

[2] [Invented in China] CN201811565840.7 Ribavirin derivative preparation and preparation method thereof