applications of 4-(pyridin-2-yl)thiazol-2-amine_industrial additives

application background and overview of 4-(pyridin-2-yl)thiazol-2-amine

4-(pyridin-2-yl)thiazol-2-amine is an organic amine compound that can be used as an intermediate in organic synthesis. if 4-(pyridin-2-yl)thiazol-2-amine, neodymium carbonate is inhaled, move the patient to fresh air; if skin contact occurs, remove contaminated clothing and wash skin thoroughly with soap and water, if necessary if you feel unwell, seek medical attention; if eye contact occurs, separate eyelids, rinse with running water or saline, and seek medical attention immediately; if ingested, rinse mouth immediately, do not induce vomiting, and seek medical attention immediately.

application structure of 4-(pyridin-2-yl)thiazol-2-amine

applications of 4-(pyridin-2-yl)thiazol-2-amine

4-(pyridin-2-yl)thiazol-2-amine can be used as an intermediate in organic synthesis. for example, prepare the following compounds:

add 1.28g (0.0072mol) of 4-(pyridin-2-yl)thiazol-2-amine into a 50ml three-necked flask, and dissolve 10ml of tetrahydrofuran. then use 10 ml of dry tetrahydrofuran to dissolve 4-methyl-1,2,3-thiadiazole-5-formyl chloride, and slowly add it dropwise at a temperature lower than -5°c. after the addition is complete, add 5 ml of triethylamine and stir at room temperature. after reacting for 12 hours, the solid was filtered off, and the solvent was evaporated under reduced pressure to obtain a yellow oily liquid.

add a small amount of dcm to the oily liquid and shake while adding until a large amount of solid precipitates. filter out the solid, and wash the filter cake with 10% sodium hydroxide aqueous solution, water, and saturated sodium chloride aqueous solution in sequence. dry over anhydrous sodium sulfate to obtain the title compound as a yellow solid 0.99g, yield 41.1%, melting point 179-180°c. 1hnmr (mhz, dmso-d6): δ13.40 (brs, 1h), 8.63 (m, 1h), 8.01 (m, 3h), 7.37 (m, 1h), 2.89 (s, 3h). hrms(esi)c13h10on4cls2[m+h]+theoretical value is 336.99791, and the experimental value is 336.99807.

application and preparation of 4-(pyridin-2-yl)thiazol-2-amine

the preparation of 4-(pyridin-2-yl)thiazol-2-amine is as follows: add 2.0g (0.01mol) of α-bromo-2-pyridine ethanone and 0.76g of thiourea ( 0.01mol) and 50ml ethanol, reflux reaction for 4h. after the reaction is completed, the ethanol solvent is evaporated under reduced pressure. column chromatography separation, using dcm:meoh:nh4oh (20:1:0.1, v/v=50:1:0.1) as the mobile phase. the title compound 4-(pyridin-2-yl)thiazol-2-amine was obtained as a white solid 1.41 g, yield 79.6%, melting point 178-179°c. 1hnmr (mhz, dmso-d6): δ8.54(m, 1h), 7.82(m, 2h), 7.25(m, 2h), 7.11(brs, 2h).ms(esi)m/z[m+h ]+199.97.