main applications of 1-methoxy-2-methyl-2-propanol_industrial additives

background and overview^[1]

1-methoxy-2-methyl-2-propanol can be used as a pharmaceutical synthesis intermediate. if 1-methoxy-2-methyl-2-propanol is inhaled, move the patient to fresh air; if skin contact occurs, remove contaminated clothing and rinse skin thoroughly with soap and water. if discomfort occurs if you feel sick, seek medical attention; if eye contact occurs, separate eyelids, rinse with running water or saline, and seek medical attention immediately; if ingested, rinse mouth immediately, do not induce vomiting, and seek medical attention immediately.

preparation^[1]

1-methoxy-2-methyl-2-propanol is prepared as follows: 10.8g (0.1mol) 1-chloro-2-methyl-2-propanol in 30ml methanol under argon. treat with 20.4 ml of methanol solution of sodium methoxide (110 mmol; 1.1 equivalent), and the mixture is refluxed under boiling conditions for 2.5 h. after the reaction is completed, the precipitate is removed by filtration, the solvent is distilled off through a vigreux column, and the residue is distilled under standard pressure to obtain the title compound: h-nmr (200mhz; cdcl3)=3.33/s (3h); 3.15/s(2h); 1.13/s(6h). fab-ms(m+h)=105.

apply^[1]

1-methoxy-2-methyl-2-propanol can be used as a pharmaceutical synthesis intermediate. for example, prepare (1,1-dimethyl-2-methoxy)ethyl chloroformate: 770 mg (2.59mmol) bis(trichloromethyl)carbonate (triphosgene; fluka,

buchs, switzerland) was dissolved in 25 ml of diethyl ether, and the solution was treated with 737 mg (7.07 mmol) of 1-methoxy-2-methyl-2-propanol dissolved in a small amount of diethyl ether in an ice bath. cool and treat slowly with a solution of 0.67 ml (8.48 mmol) of pyridine in 3 ml of diethyl ether. after the addition was complete, the ice bath was removed and the mixture was then stirred at rt for 1 h. the reaction mixture was filtered through a plug filter and the solvent was distilled off at rt to give crude product (title compound). ir(ch2cl2): inter alia: 1780, 1210, 1198, 1145 and 1120cm.

main reference materials

[1] cn95120506.4 ether-free antiviral aspartic protease substrate isostere