Preparation and application examples of isopropyl alcohol pinacol borate_Industrial additives

Background and overview^[1-5]

Isopropyl alcohol pinacol borate is an organic intermediate that can be obtained by the heating reaction of triisopropyl borate and pinacol. There are reports in the literature that it can be used to prepare high-strength binders for corrugated paper, polymer absorbers, and water-resistant and antibacterial plastic masterbatch.

Preparation^[5]

Add triisopropyl borate (261.0 g, 1.388 mol) and pinacol (142.5 g, 1.207 mol) to a 20-liter four-neck flask and heat to ~90°C for 12-16 hours. The criterion for reaction completion was pinacol <4.0% by GC. Upon completion, the reaction is converted to distillation and the product fraction is collected (boiling at 174-178°C). The title product was obtained as a colorless oil in a yield range of 80-90% in six 20 liter batches run. GC recorded 87‑96% purity, but 1H NMR indicated that the product was very pure.

Apply^[1-4]

Application 1,

CN201710559258.9 discloses a method for preparing a high-strength adhesive for corrugated paper, which includes the following steps: (1) Add starch to warm water at 60-70°C, mix and stir evenly, and then add a volume fraction of Keep the temperature of the reaction system at 45-55°C with 30% hydrogen peroxide and the reaction time at 40-50 minutes to prepare oxidized starch; (2) Add D-methyl lactate and ethylenediamine propyl sulfonate to the prepared oxidized starch. Sodium phosphate, isopropyl pinacol borate, tetrabutylammonium fluoride, dibutylthiourea, and nano zinc oxide, mix and stir evenly, then continue to add silane coupling agent KH-540 to them, mix and stir evenly. Finally, the finished product is obtained. The method for preparing a high-strength adhesive for corrugated paper provided by the invention is simple to operate. The high-strength adhesive produced is safe and environmentally friendly, has excellent water resistance, has no irritating odor, and has high bonding strength.

Application 2,

CN201710110993.1 discloses a polymer absorbent prepared by using waste plastics, including the following weight components: 40-70 parts of waste plastics, 3-8 parts of kaolin, 4-8 parts of asbestos powder, etc. 2-6 parts of phenylammonium chloride, 10-15 parts of butyl methacrylate, 10-15 parts of myristyl acrylate, 7-12 parts of isobutyl 2-butenoate, 10-16 parts of pyruvic aldehyde, 4-hydroxyl 5-10 parts of benzonitrile, 6-10 parts of isopropyl pinacol borate, 5-12 parts of 2-methyl-1,3-butadiene, and 10-18 parts of diethyl ether. The present invention takes waste plastics produced in production and life as the main body, and uses a variety of inorganic and organic substances to improve them, thereby obtaining a polymer absorbent with fast oil absorption speed, large oil absorption capacity and good oil retention performance.

Application 3.

CN201910698198.8 discloses a method for preparing acids with different substituents. The terminal alkyne is lithiated with n-butyl lithium and then reacted with isopropyl pinacol borate. Hydrogen chloride is added to quench it, and then it is quenched by an oxidizing agent. Oxidation, separation and purification yield acid. The method of the invention is simple to operate, is prepared in one pot, does not require metal catalysis, the reaction reagents used are non-toxic, green and environmentally friendly, and has high atom utilization rate. It provides a new and fast way to prepare acids with different substituents. As an important fine chemical, it is widely used in medicine, pesticides, spices and other industries.

Application 4.

CN201810919841.0 discloses a preparation method for water-resistant antibacterial plastic masterbatch, which includes the following steps: (1) Add 1,2-cyclohexanediamine to water, and then slowly add sulfuric acid to it until white precipitates. When it is no longer generated, filter, wash the filter residue, and dry to obtain 1,2-cyclohexanediaminetetraacetic acid; (2) Combine 1,2-cyclohexanediaminetetraacetic acid and isopropanol pinacol Add boric acid ester, disodium sebacate, stearyl monoglyceride citrate, and nano-ITO into the high-speed mixer, and mix evenly to prepare a water-resistant antibacterial agent; (3) Combine the water-resistant antibacterial agent and polyethylene resin After mixing evenly according to the ratio of 1:4-6, add it to the twin-screw extruder, and after extrusion and granulation, the functional masterbatch is obtained. The water-resistant antibacterial plastic masterbatch prepared by the invention has excellent mechanical properties and excellent aging resistance, especially good blistering resistance. After long-term blistering treatment, it still has excellent antibacterial properties.

References

[1] CN201710559258.9 Preparation method of high-strength adhesive for corrugated paper

[2] CN201710110993.1 A polymer absorbent prepared by using waste plastic and its method

[3] CN201910698198.8 Preparation method of acids with different substituents

[4] CN201810919841.0 Preparation method of water-resistant antibacterial plastic masterbatch

[6] [Chinese invention] CN201180031841.3 7-(1H-pyrazol-4-yl)-1,6-naphthyridine compound as SYK inhibitor