Preparation and Application of Laureth-4_Industrial Additive

Background and overview^[1]

Laureth-4 is a polyether defoamer. Polyether defoamer is a major variety of defoamer at present. It is non-toxic, odorless, non-irritating, resistant to hard water, acid and alkali, and compatible with The advantages of dimethyl silicone emulsifiers include good system compatibility. Compared with another major category of silicon-containing defoaming agents, although its defoaming performance is not high, its foam suppression performance is quite excellent.

Laureth-4 is used as an antistatic agent and emulsifier in cosmetics. It should be noted that it may cause skin allergies and acne.

Preparation^[1]

General synthesis method: Under argon protection, add iodoalkane (1eq.) to a DMF (40mL) solution containing triethylene glycol or tetraethylene glycol (1eq.), and cool the mixture to 0 ℃, add sodium hydride (1.5eq.60% in mineral oil), stir for 2 hours, add water to quench, extract with ethyl acetate (20mL×2), combine the ethyl acetate phases, wash with saturated brine, and then anhydrous It was dried over sodium sulfate and concentrated to obtain a crude product, which was purified by silica gel column chromatography (ethyl acetate-n-hexane) and the sample was immediately used for the next reaction.

Laureth-4 was synthesized using the above general synthesis method, tetraethylene glycol (2mL, 11.59mmol) and 1-iodododecane (4.42g, 11.59mmol), sodium hydride (0.70g, 17.38 mmol) reaction to obtain laureth-4 (2.18 g, 6.02 mmol, yield 52%) as a colorless oil; Rf = 0.41 (ethyl acetate-n-hexane 3:2).

Apply^[2-3]

CN201811249391.5 discloses a makeup remover composition and its preparation method and application. The makeup remover composition is mainly made of the following raw materials in terms of weight percentage: 20% to 60% vegetable oil, 10% to 30% Laureth sulfate salt, 15% to 30% laureth-4, 5% to 25% emollient, 1% to 10% foam stabilizer and 0 to 1% plant acne remover. The makeup-removing composition has good makeup-removing effect, does not require secondary cleaning, is gentle and non-irritating to the skin, and has good moisturizing effect.

CN201911332927.4 discloses a bubble bath oil and a preparation method thereof, which includes the following components in weight percentage: sweet almond oil: 30-55%, cocamide DEA: 1-4%, laurel Polyether sulfate TIPA salt: 15-25%, propylene glycol: 3-8%, laureth-4: 20-35%, PEG-7 glyceryl cocoate: 1-4%, auxiliary ingredients: 0.5 %-1%, the bubble bath oil of the present invention can not only remove dirt and excess sebum on the skin, but also maintain the oil balance of the skin, improve the condition of itchy and dry skin, increase the lubrication of the skin, and simultaneously cleanse. With nourishing effect, it is a true two-in-one cleaning and care product.

Main reference materials

[1] [Chinese invention] CN201910306197.4 Drug carrier based on the liposome structure of sulfonium rubber antioxidant and its preparation method and use

[2] CN201811249391.5 Makeup removal composition and preparation method and application thereof

[3] CN201911332927.4 Bubble bath oil and preparation method thereof