Preparation of 2-phenyl-2-propanol_Industrial additives

Background and overview^[1][2]

2-Phenyl-2-Propanol (2P2P), also known as 2-Phenylisopropanol (2-Phenylisopropanol) and Dimethylbenzylalcohol, has the chemical formula C9H12O, 2-Phenyl-2-propanol is somewhat toxic and can cause physical harm if swallowed. Contact can also cause eye irritation. 2-Phenyl-2-propanol has a rose aroma and is an additive for perfumes and cosmetics. It is also an important intermediate for the industrial synthesis of dicumyl peroxide. Its synthesis method mainly uses cumene hydroperoxide as raw material, including inorganic reducing agent reduction method and catalytic hydrogenation method. At present, the industrial synthesis of 2-phenyl-2-propanol adopts the inorganic reducing agent reduction method. The synthesis process is as follows: air is used as the oxidant, and alkali solution is used as the additive to catalytically oxidize cumene to prepare cumene hydroperoxide (CHP). ; Then use sulfide alkali (NaS or Na2SO3) to reduce CHP to prepare 2-phenyl-2-propanol. This method has high selectivity, but will produce a large amount of alkaline or sulfur-containing wastewater. The subsequent wastewater treatment process is cumbersome, neither economical nor environmentally friendly; 2-phenyl-2-phenyl- 2-Propanol, the process is more complicated. Therefore, finding an efficient and environmentally friendly catalyst for one-step synthesis of 2-phenyl-2-propanol using cumene as raw material has become the research direction of this process.

2-Phenyl-2-propanol

Apply^[3]

Currently, 2-phenyl-2-propanol is mainly used as a solvent in the production process of ethylene-vinyl acetate copolymer (EVA). EVA monomer is a viscous liquid mainly used in the manufacture of coatings and adhesives. It can also be copolymerized with vinyl chloride, styrene and other monomers to form EVA plastic to improve the hardness of styrene and other monomers and increase elasticity and toughness.

Preparation^[2]

(1) Add cumene and solid catalyst to the reactor, and conduct ultrasonic treatment to form a suspension; the solid catalyst is a nitrogen-doped carbon material, and the nitrogen-doped carbon material is nitrogen-doped carbon nanotubes, doped Nitrogen graphene or nitrogen-doped activated carbon; in terms of mass percentage, the nitrogen-doping amount of the nitrogen-doped carbon material is 2 to 4.0%; the weight ratio of the nitrogen-doped carbon material solid catalyst to cumene is 0.006 to 0.012:1;

(2) Heat the obtained suspension to 40-100°C, introduce oxygen, and react under normal pressure for 1-12 hours; the oxidant is introduced by bubbling, and the oxygen flow rate is 0.5 per milliliter of cumene. ~1.5mL/min;

(3) After the reaction in step (2) is completed, separate the reaction mixture to obtain a solid catalyst and a liquid mixture containing 2-phenyl-2-propanol, acetophenone and cumene hydroperoxide. ;

(4) Separate and purify the liquid mixture in step (3) to obtain the target products 2-phenyl-2-propanol and acetophenone.

Main reference materials

[1] Chen Wanfang, Mu Jianghua, & Qian Mingwei. (2011). Determination of the release of acetophenone and 2-phenyl-2-propanol in Eva materials. Guangdong Chemical Industry, 38(009) , 137-138.

[2] Mao Shulu, Zhang Yuanjin, Chen Bin, You Zhiyong, Lian Xiaobin, & Yin Honglei. (2015). Research on detection methods of acetophenone and 2-phenyl-2-propanol in Eva materials. China Leather, 44(010), 104-109.

[3] Kong Yang, & Zhou Xinrui. (2019). Method for preparing 2-phenyl-2-propanol at room temperature. CN109503328A.