preparation of 4-pyridinecarboxamide_industrial additives

preparation background and overview of 4-pyridinecarboxamide

4-pyridinecarboxamide is a pyridine derivative containing an amide functional group. polycarbonate amide functional group is a very important type of functional group in organic compounds. many natural compounds, pharmaceutical intermediates and high value-added fine chemicals contain amide functional groups.

preparation of 4-pyridinecarboxamide

preparation report 1 of 4-pyridinecarboxamide,

(1) preparation of nitrogen atom-doped porous carbon materials: dissolve 6 g glucose, 15 g silica sol, and 5 g urea in 50 g distilled water, and stir at 100°c for 36 hours. the obtained mixture was dried at 150°c for 2 hours, and then carbonized at 1200°c for 2 hours under inert atmosphere conditions to obtain black powder. the black powder is treated with a template removal agent for 12 hours, filtered, washed with distilled water until the ph is about 7, and then dried in a vacuum to obtain a nitrogen-doped porous carbon material.

(2) synthesis of 4-pyridinecarboxamide: weigh 0.1g nitrogen-doped porous carbon material, 0.5g 4-methylpyridine, and 0.4g urea, add them to the high-pressure reaction kettle, and replace them with oxygen three times. , fill with oxygen to 10 mpa, raise the temperature to 50°c, and react for 48 hours; after the reaction is completed, cool to room temperature. the reaction solution was analyzed by gas chromatography, and the yield of 4-pyridinecarboxamide was 81%.

preparation report 2 of 4-pyridinecarboxamide

add 100mg ferric oxide, 100mg tricobalt tetroxide and 10 battery grade lithium carbonate to 6g tert-amyl alcohol, 0mg manganese dioxide (mass percentage in the mixture: 4.6%), 60mg 4-cyanopyridine (in the mixture mass percentage: 0.91%), 200ul water (mass percentage in the mixture: 3.0%), mix evenly; react at 80°c for 24 hours, 4-cyanopyridine conversion rate is 99.0%, corresponding selection of 4-pyridinecarboxamide safety is 99.0%.

references

[1] [chinese invention] cn202010203137.2 a method for synthesizing amide compounds from heterocyclic compounds using non-metal porous carbon catalysis

[2] [chinese invention] cn201910531204.0 method for preparing amide compounds by using oxide materials to catalyze the hydration of organic nitriles