Safety/bioavailability/efficacy study of organic yeast zinc

Safety/bioavailability/efficacy study of organic yeast zinc

Different Zinc – Yeast/Zinc Ferment

Currently, cosmetic raw materials containing zinc are widely used, and there are 32 kinds included in the “Catalogue of Names of Used Cosmetic Raw Materials (2015 Edition)”. And the yeast/zinc ferment is the most distinctive of all the zinc-containing ingredients.

Add inorganic zinc to the medium during the growth of yeast, use the yeast to absorb and transform zinc to obtain zinc-rich yeast, and then use biological enzymatic technology to separate the zinc-rich yeast intracellular content, so as to obtain Yeast/Zinc Ferment.

Compared to the obvious irritation and low bioavailability of inorganic zinc and chemically synthesized zinc raw materials, yeast/zinc fermentation products have high bioavailability, safety and easy absorption due to the advantages of organic combination It has unique efficacy characteristics in cell proliferation, skin repair, oil control and antibacterial, and skin microecological regulation.

Security

Through cooperation with the French National Center for Scientific Research, it is found that the zinc element in the yeast/zinc fermentation product is mainly combined with proteins, polypeptides, amino acids, citric acid, maleic acid, succinic acid and other components in yeast cells. Various organic combination forms effectively improve the irritation and low absorption and availability problems of inorganic zinc. After short-term exposure in vitro test, in vitro skin sensitization test: ARE-Nrf2 luciferase keratin TM test and human cell line activation test (H-CLAT), human patch test, we found that yeast/zinc The fermented product is safe and reliable, without any irritation problem.

High bioavailability

A study of the metabolic kinetics of yeast/zinc fermentation products in rats was published in Molecular Nutrition Food Research. According to the test results, compared with zinc sulfate and zinc citrate, the bioavailability of yeast zinc fermentation product is 38.4% and 15.5% higher than the two respectively, and the advantage of yeast/zinc fermentation product organic form zinc is in the large Well-documented in murine metabolic kinetic assays.

Promote cell proliferation

According to the efficacy and characteristics of enzymes related to skin care (SOD superoxide dismutase, MMP metalloproteinase, AP alkaline phosphatase, RNA and DNA polymerase) in which zinc element participates, Angel has the effect on yeast zinc The efficacy of the fermentation products in terms of cell proliferation and skin repair was evaluated.

Yeast/zinc fermentation products have obvious proliferation-promoting effects at concentrations of 0.078%, 0.156%, 0.313%, 0.625%, 1.25%, and 2.5% at 48 hours; zinc and its amino acids and proteins , trace elements, etc. provide sufficient nutrition for cell proliferation.

Promote cell repair

The repairing effect of the yeast/zinc fermentation product was verified by the method of cell scratching. Compared with the blank group, the sample group had obvious promoting effect on fibroblast migration at the concentration of 1% and 2% (p <0.01). Zinc-rich amino acid peptides and other components are more conducive to cell metabolism and absorption. After entering the cells, they can effectively combine with intracellular proteins and other substances, and participate in the regulation of many genes and enzyme activities in the body, including cell division, growth and differentiation.

Related clinical trials

Select 30 subjects to test whether the yeast/zinc fermentation product can play a role in oil control, antibacterial, skin and scalp care.

Using yeast/zinc hair with varying amounts of formula�� product, and use SM815 (German CK company) to detect the skin lipid content and change rate of forehead and cheek for 4 hours. It was found that the yeast/zinc fermentation product can significantly reduce the oil secretion of the skin, and there is a dose-dependent relationship. This shows that zinc in organic form has its unique aspect in oil regulation.

In terms of bacteriostasis, it can be seen from the results in the above figure that yeast/zinc fermentation products can exert a certain inhibitory effect on P. acnes at a certain concentration.

Aiming at adolescent acne and scalp problems, yeast zinc fermentation products can exert its unique comprehensive effects. With the rise of temperature and the arrival of summer, the secretion of cortex in the skin increases, and the excessive proliferation of oleophilic fungi further leads to the imbalance of skin flora, which in turn causes problems such as itching, hyperplasia of stratum corneum cells, and abnormalities. The irritation and itching of the skin induces scratching and excessive cleaning, triggers an inflammatory response, accelerates the abnormal differentiation of keratinocytes, and then destroys the skin barrier. The increased stimulation of environmental foreign substances in the later stage will further lead to the imbalance of skin microecology.

Sorting out the efficacy and characteristics of yeast/zinc fermentation products:

First of all, the role of zinc is to regulate oil metabolism to a certain extent through external application or oral administration, reduce excessive oil secretion, thereby inhibiting fungal growth and regulating the balance of flora; at the same time, zinc can also promote cell division and promote skin health. In addition, zinc can also regulate the immune response in skin cells, improve the immune balance of the skin, and restore the skin barrier function.

With the continuous improvement of the market’s demands for safety, health and high efficiency, yeast/zinc fermentation products with homologous makeup and food are widely used in the food field, organic form, safety, high bioavailability, and in the repair In-depth research in the fields of efficacy, oil control, antibacterial, etc., the future application prospects are promising.