Safety/Bioavailability/Efficacy Study of Organic Yeast Zinc

Safety/bioavailability/efficacy research on organic yeast zinc​

Different zinc – yeast/zinc fermentation product

At present, cosmetic raw materials containing zinc are widely used, and there are 32 types in the “Catalogue of Names of Used Cosmetic Raw Materials (2015 Edition)”. Yeast/zinc fermentation is the most distinctive of all zinc-containing ingredients.

Inorganic zinc is added to the culture medium during the growth process of yeast, and zinc-rich yeast is obtained by utilizing the absorption and transformation of zinc elements by yeast. The zinc-rich yeast intracellular contents are then separated through biological enzymatic hydrolysis technology to obtain Yeast/zinc fermentation product.

Compared with inorganic zinc and chemically synthesized zinc raw materials, which have obvious irritation and low bioavailability, yeast/zinc fermentation products have high bioavailability, safety and easy absorption due to the advantages of organic combination. It has unique efficacy characteristics in cell proliferation, skin repair, oil control and antibacterial, and skin microecological regulation.

Security

Through cooperation with the French National Center for Scientific Research, it was discovered that the zinc element in yeast/zinc fermentation products mainly exists in yeast cells in combination with proteins, peptides, amino acids, citric acid, maleic acid, succinic acid and other components. Various organic combination forms effectively improve the irritation and low absorption and availability problems of inorganic zinc. We found that yeast/zinc The fermentation products are safe and reliable without any irritation issues.

High bioavailability

A study on the metabolic kinetics of yeast/zinc fermentation products in rats was published in Molecular Nutrition Food Research. It can be seen from the experimental test results that compared to zinc sulfate and zinc citrate, the bioavailability of yeast zinc fermentation products is 38.4% and 15.5% higher than the two respectively. The advantages of yeast/zinc fermentation products in the form of organic zinc are in large It has been fully demonstrated in mouse metabolic kinetics experiments.

Promote cell proliferation

According to the efficacy and characteristics of enzymes related to skin care (SOD superoxide dismutase, MMP metalloprotease, AP alkaline phosphatase, RNA and DNA polymerase) that zinc participates in, Angel’s zinc for yeast The fermentation products were evaluated for their efficacy in cell proliferation and skin repair.

The yeast/zinc fermentation product has obvious proliferation-promoting effect at 48 hours at concentrations of 0.078%, 0.156%, 0.313%, 0.625%, 1.25%, and 2.5%; zinc element and the amino acids and proteins in it , trace elements, etc. provide sufficient nutrients for cell proliferation.

Promote cell repair

The repair efficacy of yeast/zinc fermentation products was verified by cell scratching. Compared with the blank group, the sample group had an obvious pro-migration effect on fibroblasts at concentrations of 1% and 2% (p <0.01). Ingredients such as zinc-rich amino acid peptides are more conducive to cell metabolism and absorption. After entering the cells, they can effectively combine with intracellular proteins and other substances, and participate in the regulation of many genes and enzyme activities in the body, including cell division, growth and differentiation.

Related clinical trials

Select 30 subjects to test whether yeast/zinc fermentation products can play a role in oil control, antibacterial, skin and scalp care.

Use formulas with different contentsYeast/zinc fermentation product, and use SM815 (CK Company, Germany) to detect the skin lipid content and change rate of the forehead and cheeks for 4 hours. The results showed that yeast/zinc fermentation products can significantly reduce skin oil secretion in a dose-dependent manner. This shows that zinc in organic form has its own unique aspect in regulating oil.

In terms of antibacterial activity, it can be seen from the results in the above figure that at a certain concentration, yeast/zinc fermentation products can exert a certain inhibitory effect on Propionibacterium acnes.

For adolescent acne and scalp problems, yeast zinc fermentation products can exert its unique comprehensive effects. As the temperature rises, cortical secretion in the skin increases with the arrival of summer, and the excessive proliferation of oil-loving fungi further leads to an imbalance of skin flora, which in turn causes problems such as itching, horny cell hyperplasia, and abnormalities. The irritation and itching of the skin induces scratching and excessive cleaning, triggers an inflammatory reaction, accelerates abnormal differentiation of keratinocytes, and thereby destroys the skin barrier. Later, the increased stimulation of environmental foreign substances will further lead to an imbalance of skin microecology.

Comment out the functional characteristics of yeast/zinc fermentation products:

First of all, the role of zinc is to regulate oil metabolism to a certain extent through external application or oral administration, reduce excessive secretion of oil, thereby inhibiting fungal growth and regulating the balance of flora; at the same time, zinc can also promote cell division and promote skin growth. healing; in addition, zinc can also regulate the immune response in skin cells, improve the immune balance of the skin, and restore the skin barrier function.

As the market demands for safety, health, and efficiency continue to increase, the yeast/zinc fermentation products that are homologous to food and cosmetics are widely used in the food field. They are organic, safe, and highly bioavailable, as well as in repair. , oil control, antibacterial and other functional areas, the future application prospects are promising.