Preparation of 2-bromo-1-chloro-4-trifluoromethoxybenzene_Industrial additives

Background and overview[1-2] 2-Bromo-1-chloro-4-trifluoromethoxybenzene is a pharmaceutical intermediate, which can be prepared from 2-bromo-4-(triflu…

Preparation of 3-amino-4-chlorobenzonitrile_Industrial additives

Background and overview[1-2] 3-Amino-4-chlorobenzonitrile is a pharmaceutical intermediate. It can be nitrated from p-chlorobenzonitrile to obtain 4-c…

Preparation of 2-bromo-5-methoxyphenylboronic acid_Industrial additives

Background and overview[1] 2-Bromo-5-methoxyphenylboronic acid can be used as a pharmaceutical synthesis intermediate and can be prepared from 3-metho…

Preparation and application of ethyl 3-nitrophenyl acetate_Industrial additives

Background and overview[1] Ethyl 3-nitrophenylacetate can be used as a pharmaceutical synthesis intermediate. It can be prepared by the esterification…

Preparation and application of 1-bromo-3-fluoro-5-pyrrolidinebenzene_Industrial additives

Background and overview[1] 1-Bromo-3-fluoro-5-pyrrolidine benzene is a pharmaceutical intermediate, which can be prepared by nucleophilic substitution…

Application of ethyl 4-boron-3-chlorobenzoate_Industrial additives

Background and overview[1] Ethyl 4-boron-3-chlorobenzoate can be used as a pharmaceutical synthesis intermediate and applied in Suzuki coupling reacti…

Preparation of 4,4′-bis(2-bromoacetyl)biphenyl_industrial additives

Background and overview[1] 4,4’-Bis(2-bromoacetyl)biphenyl is a key intermediate in the synthesis of the anti-hepatitis C drug daclatasvir. Daclatasvi…

Preparation and application of 1-(3-bromophenyl)pyrrole_Industrial additives

Background and overview[1] 1-(3-Bromophenyl)pyrrole is an important pharmaceutical intermediate. For example, it can be used to prepare lithium 3-(pyr…

Preparation of 2-bromo-6-(trifluoromethoxy)benzoic acid_Industrial additives

Background and overview[1] 2-Bromo-6-(trifluoromethoxy)benzoic acid can be used as a pharmaceutical synthesis intermediate. It can use 2-amino-6-(trif…

Preparation of 2-chloro-4-methylbenzeneboronic acid_Industrial additives

Background and overview[1] 2-Chloro-4-methylbenzeneboronic acid can be used as a pharmaceutical synthesis intermediate and is often used as a raw mate…

Preparation of Sitagliptin Impurity 13_Industrial Additives

Background and overview[1] Sitagliptin, chemical name (2R)-4-oxo-4-[3-trifluoromethyl-5,6-dihydro[1,2,4]triazole[4 , 3-a]pyrazin-7(8H)-yl]-1-(2,4,5-tr…

Preparation of 2-fluoro-4-iodoaniline_industrial additives

Background and Overview[1] 2-Fluoro-4-iodoaniline is one of the most important intermediates in the dye industry. In the dye industry, it can be used …

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