The functions and uses of organozinc reagents

Organozinc reagent is one of the earliest organometallic reagents discovered. Due to the low reactivity of organozinc reagent, it has good functional group compatibility and high chemical, regio and stereoselectivity advantages.

Zinc-acetic acid combination reagent (Zn-AcOH) is one of the traditional reducing reagents in organic chemistry. The reduction conditions are mild and selective. This reagent still plays an important role in the transformation of functional groups in organic synthesis. Alkenes first generate dialkyl-substituted peroxy compound intermediates in the ozonation reaction. Generally, they are decomposed directly after Zn-AcOH treatment without separation to generate the corresponding aldehydes or ketones.

Metal-Catalyzed Reactions Palladium-catalyzed reactions are a useful class of reactions that provide a unique method of forming carbon-carbon bonds. The advantages of this type of reaction: 1. No other oxidants are needed to catalyze it; 2. Only a catalytic amount of palladium catalyst is needed. The palladium-catalyzed carbonyl reaction is a widely used reaction in this type of reaction. Zinc, as an essential mineral element in animals, usually exists in the form of organic zinc or organic zinc chelates in the body. It reacts and absorbs with various enzymes and is converted into bioenergy. Among them, the application of organic zinc is particularly reflected in the animal husbandry industry. Adding large amounts of zinc to animal feed can effectively improve the immunity of animals and promote growth and development.

There are many methods on the market for the preparation of organic zinc reagents, but most of them require strict operating environments and complex catalytic reactions. Using anhydrous tetrahydrofuran as the solvent, the organozinc reagent can be quickly prepared through the reaction of zinc powder and benzyl chloride under the trigger of a catalytic amount of iodine, and can be directly reacted with the acylation reagent without treatment and separation to obtain Corresponding acyl compounds. The organozinc reagent prepared by this method not only has high yield, but also is simple to operate and has good reactivity.