Application examples of 2-nitro-4-pyridinecarboxylic acid_Industrial additives

Background and overview of application examples of 2-nitro-4-pyridinecarboxylic acid

2-Nitro-4-pyridinecarboxylic acid is a methoxypyridine drug intermediate. There are reports in the literature that it can be used to prepare GSK-3 inhibitors with a pyridine structure and a new anti-invasive compound.

Application examples of 2-nitro-4-pyridinecarboxylic acid

Application examples of 2-nitro-4-pyridinecarboxylic acid Application 1,

2-Nitro-4-pyridinecarboxylic acid can be used to prepare pyridine derivatives with the following structure. This compound is a GSK-3 inhibitor. GSK-3 is a proline-directed serine/threonine kinase that performs phosphorylation of multiple protein substrates. Compounds that inhibit GSK-3 may also be used to treat diabetes, inflammatory diseases such as rheumatoid arthritis and osteoarthritis, treatment-resistant depression, schizophrenia, bipolar disorder, bipolar disorder, and osteoporosis. , cardioprotection and various cancers such as glioma, non-small cell lung cancer, pancreatic cancer, breast cancer, T or B cell leukemia and multiple myeloma.

Application examples of 2-nitro-4-pyridinecarboxylic acid Application 2.

CN201380060496.5 reported that 2-nitro-4-pyridinecarboxylic acid can be used to prepare new anti-invasive compounds with the following structure. Formylphenylboronic acid In the vast majority of cancers, death is not due to the primary tumor but to metastasis derived therefrom. This malignant progression leading to tumor invasion and clinically defined by the emergence of metastasis is the end result of loss of primary cell adhesion and increased cell motility that together allow invasive cells to leave the primary tumor site and colonize various target tissues. This type of compound reported in CN201380060496.5 can prevent the invasive progression of metastatic cancer; and based on this activity, this type of compound is used to treat cancer.

References

[1][Chinese invention] CN201480072310.2 substituted pyridine derivatives used as GSK-3 inhibitors

[2][China invention, China invention authorization] CN201380060496.5 new anti-invasive compound