application of 3-chloro-4-nitropyridine_industrial additives

application background and overview of 3-chloro-4-nitropyridine

3-chloro-4-nitropyridine can be used as an intermediate for pharmaceutical and chemical synthesis. if 3-chloro-4-nitropyridine is inhaled, move the patient to fresh air; if there is skin contact, take off contaminated clothing, rinse the skin thoroughly with soap and water, and seek medical attention if you feel unwell; if the eye contact if exposed to sunlight, separate eyelids, rinse with running water or saline, and seek medical attention immediately; if ingested, rinse mouth immediately, do not induce vomiting, and seek medical attention immediately.

applications of 3-chloro-4-nitropyridine

3-chloro-4-nitropyridine can be used as an intermediate in pharmaceutical and chemical synthesis to synthesize other compounds with certain activity, such as the synthesis of substituted 1h-pyrrolo[3,2-b as a casein kinase inhibitor , 3,2-c and 2,3-c]pyridine-2-carboxamide and related analogs, such as the synthesis of n-[(2,5-dichlorophenyl)methyl]-4-nitro-pyridine- 3-amine, the specific synthesis steps are: add triethylamine (8.35ml, 60mmol) and (2,5-dichloro phenyl)methylamine hydrochloride (8.5 g, 40 mmol) tricyclohexylphosphine fluoroborate at 0°c. the reaction mixture was heated at 80°c for 1 h, then concentrated in vacuo and diluted with ethyl acetate (40 ml). the organic layer was washed with brine (2 × 20 ml), dried over anhydrous sodium sulfate, then filtered and concentrated in vacuo. the crude material was purified by column chromatography (sio2, 1% meoh in dcm) to give the title compound n-[(2,5-dichlorophenyl)methyl]-4-nitro-pyridin-3-amine (1.7 g , 80%). δh (mhz, cdcl3) 9.27 (s, 2h), 8.57 (br s, 1h), 8.32 (d, 1h, j6.0hz), 7.38 (d, 1h, j 8.4hz), 7.30-7.26 (m, 1h ), 6.60 (d, 1h, j methyltetrahydrofuran 6.0hz), 4.64 (d, 2h, j 6.0hz).