application of 5-chloro-2-fluoropyridine_industrial additives

application background and overview of 5-chloro-2-fluoropyridine

5-chloro-2-fluoropyridine can be used as an intermediate for pharmaceutical and chemical synthesis. if 5-chloro-2-fluoropyridine is inhaled, move the patient to fresh air; if the skin comes into contact, take off contaminated clothing, rinse the skin thoroughly with soap and water, and seek medical treatment if you feel uncomfortable; if the eyes are clear in case of contact, separate eyelids, rinse with running water or saline, and seek medical attention immediately; if ingested, rinse mouth immediately, do not induce vomiting, and seek medical attention immediately.

applications of 5-chloro-2-fluoropyridine

5-chloro-2-fluoropyridine can be used as an intermediate for pharmaceutical and chemical synthesis. examples of its application are as follows:

applications of 5-chloro-2-fluoropyridine 1. it can be used to prepare a modified activated carbon adsorbent with adsorption properties for orthophosphate in water.

after cleaning the activated carbon, it is modified with a mixture of 3-bromo-4-fluoronitrobenzene and 5-chloro-2-fluoropyridine to prepare substance c; substance c is treated with nbcl₄ , incl₃, sr(no₃)₂, mn(no₃)₂ sub>the prepared mixed solution was modified to prepare substance d; substance d was treated with 3-bromo-2-fluorotoluene, 1-bromo-2-iodotetrafluoroethane, 3-chlorothiophene-2-carboxylic acid methyl ester, 2 the mixed liquid prepared from -hydroxy-3-pyrazinecarboxylic acid methyl ester was modified to prepare substance f; substance f was treated with nitrobenzene borate pbcl₂, cucl₂, the substance obtained after modification of the mixed solution prepared by co(no₃)₂ and mg(no₃)2 is the substance in the water body. orthophosphate is a modified activated carbon adsorbent with adsorption properties.

applications of 5-chloro-2-fluoropyridine 2. for the preparation of methyl 2-[1-(5-chloropyridin-2-yl)piperidin-4-yl]acetate.

the specific steps are: combine 5-chloro-2-fluoropyridine (500mg, 3.80mmol), diea (1.5g, 11.61mmol), methyl 2-(piperidin-4-yl)acetate (599mg, 3.81mmol) ) solution dissolved in dmso, stirred at 90°c for 16 hours under n2. the resulting solution was extracted with 2×50 ml etoac, and the combined organic layers were concentrated in vacuo and purified by silica gel chromatography using etoac/hexane (1/1) to afford 700 mg (69%) of the title compound as a white solid over sodium carbonate. ms (es, m/z): 268.9